Endocrine Abstracts

Background: There are increasing evidences that inflammation is involved in the pathophysiology of both coronary heart disease and cerebrovascular disease. Adhesion molecules have been advocated as a marker of inflammation.Objectives: To evaluate the capacity of inflammation’s markers (sICAM1, sVCAM1) to identify cardiovascular disease, comparing adhesion molecules with a standard diagnosis of cardiovascular disease.Methods: W...

Background: Metabolomics profiling of bio-fluids suggests altered signatures in patients with the polycystic ovary syndrome (PCOS).Subjects and methods: A high-performance liquid chromatography/time-of-flight mass spectrometry (HPLC/TOF-MS)-based metabolomics approach was developed to characterize the untargeted lipidomics signature associated with PCOS status in a discovery cohort of 30 plasma samples (15 PCOS, 15 controls, age-matched), followed in a s...

Introduction: Secondary hyperparathyroidism (sHPT) is a prevailing complication of chronic kidney disease (CKD) caused by the disturbance of calcium, phosphate, and vitamin D, with high concentrations of serum parathormone (PTH) leading to high rates of cardiovascular and bone disease. The incidence and prevalence of chronic kidney disease, including kidney failure requiring renal replacement therapies (RRT) is rising in Europe. The objective of this study is to determine usin...